The SOCS7 antibody - N-terminal region (ARP53700_P050) from Aviva Systems Biology is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The SOCS7 antibody - N-terminal region (ARP53700_P050) has been validated for the following applications: Western Blot.
Description
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins